WebAug 15, 1992 · A fifth cryptdin is the first defensin to diverge from the previously invariant spacing of cysteines in the peptide structure. The most abundant enteric defensin, cryptdin-1, had antimicrobial activity against an attenuated phoP mutant of Salmonella typhimurium but was not active against the virulent wild-type parent. WebMar 20, 2005 · In situ hybridization on the intestines of APC Min mice revealed that the Paneth-cell genes MMP7 (c and ref. 14), EphB3 (d and ref. 9), cryptdin-1 (e) and cryptdin-6 (f) are inappropriately ...
Induction of epithelial chloride secretion by channel-forming
WebIn mouse small bowel, the bactericidal cryptdin 1–6 peptides are specific to Paneth cells, and cryptdin-4 is the most potent of the known mouse cryptdins (3). Studies of mice lacking matrilysin (matrilysin-deficient), MMP-7,1 a metalloproteinase that activates Paneth cell pro-cryptdins, have shown that the resulting deficiency in activated WebMar 1, 2024 · 图 1 生物活性物质对重金属诱导的水生植物毒性的改善机制 注:红点代表重金属,绿点代表生物活性物质. 红色和绿色箭头分别代表重金属和生物活性物质引起的相关指标的升高或降低. rc and rl circuits with general sources
Mouse intestinal cryptdins exhibit circadian oscillation
WebMar 4, 2005 · Cryptdin Musashi-1 Small intestine Stem cell Paneth cell The small intestinal epithelium is characterized by continuous replacement of epithelial cells through proliferation and differentiation of a pool of progenitor cells throughout life. However, the exact mechanism of differentiation of small intestinal epithelium remains unclear. WebThe most abundant enteric defensin, cryptdin-1, had antimicrobial activity against an attenuated phoP mutant of Salmonella typhimurium but was not active against the … WebApr 13, 2024 · The expression of lysozyme 1, cryptdin 1, cryptdin 4 and mucin 2 were reduced 24h after surgery in the ileal mucosa and mucin 2 was also reduced in the jejunum. Postoperative IL-1α and IL-1β were increased in the postoperative mucosa. Deficiency of IL-1R1 affected the expression of antimicrobial peptides during homeostasis and POI. … rc and showtime