WebbHi @SKVirk27 Thanks for your interest in EPIC. MAF threshold: By default, EPIC use MAF=1%. You don't need to specify MAF. If you are interested in custom MAFs, make sure 0<1, otherwise you would get errors "Invalid MAF threshold!". WebbThe command requires a PLINK-style PED file, with the first four columns specifying a family ID, the child ID, the father ID, and the mother ID. The output of this command has the suffix ".mendel".--extract-FORMAT-info Extract information from the genotype fields in the VCF file relating to a specfied FORMAT identifier.
Linkage disequilibrium - PLINK 1.9
Webbplink --meta-analysis s1.assoc s2.assoc + report-all In this example, the report-all option means that even SNPs that are only found in a single file are reported. ... One can use the --extract option as well as --chr, etc, to input and perform meta-analysis only on certain subsets of SNPs. WebbThese PLINK binary files should contain variants merged across all autosomes that will be used to generate the genetic relatedness matrix model and variance ratio files. Phenotype file is a space or tab-delimited file with a header, containing a column for IDs of samples as they appear in the genotype data, a column for the phenotype and optional columns for … jason connelly kinder
pca with plink – Open Source Biology & Genetics Interest Group
WebbPLINK will generate a number of standard summary statistics that are useful for quality control (e.g. missing genotype rate, minor allele frequency, Hardy-Weinberg equilibrium … Webb% plink --bfile rawData --indep-pairwise 50 10 0.1 (output indicating number of SNPs targeted for inclusion/exclusion) % plink --bfile rawData --extract plink.prune.in --make-bed --out prunedData Speci cally, the rst command … Webb16 jan. 2024 · --vcf loads a (possibly gzipped) VCF file, extracting information which can be represented by the PLINK 1 binary format and ignoring everything else (after applying the … jason connell ghost of tsushima